Lymphatic Filariasis

Lymphatic filariasis is due to filarial parasites which are transmitted to humans through mosquitoes. 

When a mosquito with infective stage larvae bites a person, the parasites are deposited on the person's skin from where they enter the body. The larvae then migrate to the lymphatic vessels where they develop into adult worms in the human lymphatic system. Infection is usually acquired in childhood, but the painful and profoundly disfiguring visible manifestations of the disease occur later in life. Whereas acute episodes of the disease cause temporary disability, lymphatic filariasis (LF) leads to permanent disability.

 

Disease Burden: 

LF is endemic in 83 countries and there are an estimated 120 million cases, including 25 million men with hydroceles and 15 million people, primarily women, with lymphedema. The disease occurs throughout the tropical areas of Africa, Asia, the Americas and the Pacific, with around 66% of the infection clustered in South-East Asia and most of the remaining infection (~33%) centred in Africa.

Transmission Dynamics: 

LF is caused by a species of filarial round worms, or nematodes, with up to 90% of all infections caused by Wuchereria bancrofti. In some parts of Asia, LF is caused by Brugia malayi and Brugia timori.  Various mosquito species transmit these worms: Culex mosquitoes transmit W. bancrofti in urban and semi-urban areas, Anopheles mosquitoes transmit worms in rural environments, especially in Africa, and Aedes mosquitoes are responsible for transmission throughout the Pacific.

To learn more about the transmission dynamics of lymphatic filariasis, please visit the Global Atlas of Helminth Infections (GAHI).

Interventions: 

Numerous countries have implemented LF control programmes, with significant achievements in the Americas, the Pacific and Asia. A few countries in Africa are close to their elimination goals. To learn more about LF elimination, please visit the Global Atlas of Helminth Infections


Model code

We are committed to making our model code available for use by other modellers. Below are links to code used in recent publications:

Smith et al. Predicting lymphatic filariasis transmission and elimination dynamics using a multi-model ensemble framework Epidemics 2017. The code for EPIFIL is available here. The code for TRANSFIL is available here. The code for LYMFASIM was published with:

Jambulingam et al. Mathematical modelling of lymphatic filariasis elimination programmes in India: required duration of mass drug administration and post-treatment level of infection indicators. Parasites and Vectors 2016. The code is in the additional files at the end of the paper.

 

Useful links

Global Atlas of Helminth Infections


Modelling publications